Lamin phase separation
Tīmeklis2024. gada 8. febr. · Given the essential role of protein phosphorylation in controlling phase separation 52, it remains to be examined whether phosphorylation of NL proteins, such as lamin A/C, also contributes to ... Tīmeklis2024. gada 11. jūl. · Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. …
Lamin phase separation
Did you know?
http://genesdev.cshlp.org/content/22/7/832 Tīmeklis2024. gada 1. febr. · Interestingly, nuclear blebs, induced by PARP inhibitor and observed in A-type lamin-depleted or senescent cells, were positive on both the SC …
TīmeklisProteins, like lamin B1 and lamin A/C in eukaryotes (35, 36) and cec-4 in worms (37, 38), are known to tether heterochromatin to the nuclear envelope. ... The phase … Tīmeklis2024. gada 1. okt. · The interplay of chromatin phase separation and lamina interactions in nuclear organization. October 2024; Biophysical Journal 120(22) ...
TīmeklisThere is also growing evidence that liquid-liquid phase separation of protein and nucleic acid components is the underlying mechanism for the dynamical behavior of … TīmeklisInsights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA …
Tīmeklis1981. gada 25. febr. · The partition of proteins during phase separation in solutions of Triton X-114 is investigated. Hydrophilic proteins are found exclusively in the aqueous phase, and integral membrane proteins with an amphiphilic nature are recovered in the detergent phase. Triton X-114 is used to solubilize membranes and whole cells, and …
Tīmeklis2024. gada 21. dec. · Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating gene expression. Phase separation is increasingly being considered a driving force of chromatin folding. In … pros of youtubeTīmeklis2024. gada 31. dec. · The mutant proteins exhibited either weakened or augmented interactions between coil 1a and coil 2. The ensuing biochemical results indicated … research position madison wisconsinTīmeklisLamin Genes. Lamins are classified as A type and B type. The B-type lamins are expressed in most cell types, whereas A-type lamins, which include lamin C, are … research position paper topicsTīmeklis2024. gada 4. maijs · At the microscopic level, there are many possible interactions (e.g. electrostatic attraction between DNA and histone-tails, phase separation of the DNA … research poster apaTīmeklisArticle The interplay of chromatin phase separation and lamina interactions in nuclear organization Rabia Laghmach,1,* Michele Di Pierro,2 and Davit A. Potoyan1,3,4,* 1Department of Chemistry, Iowa State University, Ames, Iowa; 2Department of Physics, Northeastern University, Boston, Massachusetts; 3Department of Biochemistry and … proso harbor of hopeTīmeklisments that mislocalize lamin A and chromatin, with detrimental consequences for nuclear function and integrity. Importantly, phase separation of HSPB2 is regulated by HSPB3, but this ability is lost in two identified HSPB3 mutants that are associated with myopathy. Our results suggest that HSPB2 phase separation is involved in … research possibilities on group bilingualismTīmeklisThrough phase separation some proteins form liquid-like condensates or droplets which can flow, fuse and even deform when pressure is applied. In some cases the … pro soils laboratory