Paclitaxel mcf-7
WebMCF-7, a breast cancer derived cell line, was chosen by us for in vitro experimentation because it is a “Luminal A” subtype of noninvasive cell line and is highly responsive to chemotherapy, especially Paclitaxel (PTX) (Holliday and Speirs, 2011; Abu Samaan et al., 2024 ). It also shows presence of small populations of cancer stem cells ...
Paclitaxel mcf-7
Did you know?
WebPaclitaxel (Taxol), a potent drug of natural origin isolated from the bark of the Pacific yew, is widely used for treating ovarian, lung and breast cancers. Currently, there is little information regarding the specific mechanism underlying the anticancer activity of paclitaxel. ... MCF-7 Cells Medicine & Life Sciences 71%. Paclitaxel Medicine ... WebPaclitaxel Induces Increased Protein Expression of FoxO3a, Bim, and p27Kip1 in a Drug-sensitive Breast Cancer Cell Line—To study the role of FoxOs in determining the apoptotic response to paclitaxel in MCF-7 and MDA-MB-231 cells, we compared the changes in protein expression following treatment with paclitaxel at either 10 or 75 n m. Whole ...
Web肿瘤所处微环境乏氧能使肿瘤对放化疗的抗拒性增加，从而降低其治疗疗效。因此，深入研究低氧在乳腺癌化疗诱导凋亡中的作用和机制，从新的视角阐明乳腺癌化疗耐药的可能机制，可为乳腺癌临床化疗增敏提供参考依据。 WebMay 1, 2008 · Ghada Ajabnoor, Patricia Macanas-Pirard, Christine Shotton, Helen Coley; Paclitaxel-resistant MCF-7 cells show a caspase-less phenotype but retain sensitivity to …
WebApr 7, 2014 · Taxol (paclitaxel) is a widely used chemotherapeutic drug for various types of human cancers. The drug works by stabilizing microtubules to induce cell cycle arrest and prevent cell proliferation [6]. Studies have shown that taxol induces cell cycle arrest in breast cancer cell line MDA-MB-231 at the G2/M phase [7]. Weberibulin and paclitaxel. As there are numerous conflicting reports of whether or not certain cas-pases are required for the death-inducing capabil-ity of paclitaxel, we analyzed …
The MCF-7cell line was purchased from NCCS, Pune; maintained with RPMI 1640, 10% fetal bovine serum (FBS), 1% penicillin/streptomycin, at 37 °C in a 5% CO 2 humidified atmosphere. All chemicals used in this study were of analytical grade. 2.1. Cell viability by MTT assay
WebAs known, MCF-7/ADR cell line was a typical resistant human breast cancer cell line of DOX with cross resistance to PTX. 39 The IC 50 value of Taxol (free PTX) was 53.25 and 2.28 … golden shoutmonWebSingle and combined treatment of MCF-7 cells. In single drug treatment, MCF-7 cells (5,000/well) were harvested in 96-well plates and then were treated with increasing serial … golden shouldered parrot threatsWebSingle and combined treatment of MCF-7 cells. In single drug treatment, MCF-7 cells (5,000/well) were harvested in 96-well plates and then were treated with increasing serial concentrations of silibinin, cisplatin and paclitaxel alone for 24 and to study the drug efficacy in induction of apoptosis. Consequently, the IC 50 values hd of woodlandsWebJun 27, 2007 · This review describes the main molecular mechanisms of resistance to paclitaxel and docetaxel identified so far, focusing on the advances achieved in the development of new taxanes potentially useful for the treatment of resistant tumors. Citing Literature Volume 2, Issue 7 July 9, 2007 Pages 920-942 golden shouldered parrot life cycleWebApr 29, 2024 · MCF-7 cells were transfected with a vector containing the OCT3 gene, and a single clone with high levels of OCT3 gene expression (OCT3-MCF7) was isolated (Figure 1 ). High OCT3 gene expression in the isolated clone was accompanied by high OCT3 protein expression as determined by Western blot analysis (Figure 1 a, inset). hd of wpgWebJan 26, 2012 · Paclitaxel-resistant MCF-7 cells show an unusual spectrum of cross-resistance in the presence of P-glycoprotein We tested whether a multidrug resistant (MDR) phenotype was present by... hdo hedisWebHere, we hypothesized that coralyne in combination with paclitaxel may exhibit synergistic effect on inhibition of proliferation, migration and induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cell lines. hd of virginia